IN SILICO PREDICTION OF THE MITIGATIVE POTENTIAL OF CURCUMIN AGAINST DELTAMETHRIN TOXICITY

Authors

  • Pragnesh Patel
  • Chirag Patel
  • Himanshu Pandya
  • Ketaki Desai

DOI:

https://doi.org/10.56588/iabcd.v1i2.40

Keywords:

Deltamethrin (DLM), Curcumin (CUR), Hepatotoxicity, Molecular docking

Abstract

Deltamethrin (DLM) is a widely used pyrethroid, pest control insecticide due to restriction on the sale of organophosphate. Deltamethrin (DLM) being a potent hepatotoxic compound, that affects physiological functions of liver; however, the implications of the hepatotoxic effects of DLM on the mammalian system and its influence on the hepatic enzymatic activity are still unclear. Curcumin (CUR), a major polyphenol component of Curcuma longa Linn, is a potent antioxidant often used in traditional medicine as an ameliorative agent. However, its underlying mechanism as an anti-oxidant against DLM-toxicity remains unknown. Hence, the present study has been designed to determine the binding affinity of DLM to a hepatic enzyme marker such as Aspartate aminotransferase (AST). Moreover, the study is aimed to delineate the role of CUR on DLM-induced hepatotoxic effects through a computational approach. The molecular docking carried out demonstrated that CUR manifests a stronger binding affinity towards the liver marker enzyme, AST as compared to deltamethrin. This could explain the possible mechanism for inhibition of the toxic influence of DLM- induced reactive oxygen species on liver enzyme activity. Thus, this computational evidence validates the tenet that CUR displays anti-oxidative properties for attenuation of DLM induced hepatotoxicity, alteration in the mechanism of liver marker enzyme and its subsequent impact on hepatic tissue.

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Published

05.10.2022

How to Cite

Patel, P., Patel, C., Pandya, H., & Desai, K. (2022). IN SILICO PREDICTION OF THE MITIGATIVE POTENTIAL OF CURCUMIN AGAINST DELTAMETHRIN TOXICITY. International Association of Biologicals and Computational Digest, 1(2), 36–44. https://doi.org/10.56588/iabcd.v1i2.40

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