A COMPREHENSIVE REVIEW ON PHYTOCHEMICALS AND MEDICINAL PROPERTIES OF PUTRANJIVA ROXBURGHII WALL
Keywords:Putranjiva roxburghii, Ethnobotany, Secondary metabolites, Medicinal properties
Putranjiva roxburghii Wall. is known for its medicinal properties and credited with a significant role in Ayurvedic texts as an anti-inflammatory, antipyretic, analgesic, and anti-rheumatic herb, that is also useful to treat gynaecological and fertility disorders. Almost all parts of the plant, i.e, root, stem, leaves, fruits, and seeds contain numerous secondary metabolites such as phenolics, glycosides, triterpenes, and flavonoids. The presence of these phytochemicals imparts significant therapeutic activities to the plant such as anti-hyperglycaemic, analgesic, antioxidant, anti-inflammatory, antimicrobial and antiparasitic properties, and hence, the plant parts and its extracts can be used as a cure for varied diseases, including cancer.
Abd-Alla, H. I., Heba-tollah, M. S., El-Kashak, W. A., & El-Safty, M. M. (2019). Evaluation of immune boosting properties and combating of multiple respiratory viral infections by fifteen Euphorbiaceae plant extracts. Pharmacognosy Journal, 11(6s).
Abhimanyu, K. K., Ravindra, C. S., & Avanapu, R. S. (2018). Data on investigation of hypoglycaemic, anti-cholesterolemic, in vivo antioxidant and pancreatic beta cell protective effect of Putranjiva roxburghii Wall bark in streptozotocin-induced diabetic rats. Data in brief, 18, 1839-1846.
Ahmad, R., Parveen, G., Gauri, N. A., & Wal, N. (2017). Phytochemical screening, sugar content, total protein and antimicrobial activity of three important medicinal plants. Med. Plant, 5(6), 125-139.
Ali, S. G., Khan, H. M., Jalal, M. O. H. A. M. M. A. D., Ansari, M. A., Mahdi, A. A., & Ahmad, M. K. (2015). Green synthesis of silver nanoparticles using the leaf extract of Putranjiva roxburghii Wall. and their antimicrobial activity. Asian J. Pharm. Clin. Res, 8(3), 335-338.
Balkrishna, A., Nain, P., Joshi, M., Khandrika, L., & Varshney, A. (2021). Supercritical Fluid Extract of Putranjiva roxburghii Wall. Seeds Mitigates Fertility Impairment in a Zebrafish Model. Molecules, 26(4), 1020.
Balkrishna, A., Sharma, V. K., Das, S. K., Mishra, N., Bisht, L., Joshi, A., & Sharma, N. (2020). Characterization and anti-cancerous effect of Putranjiva roxburghii seed extract mediated silver nanoparticles on human colon (HCT-116), pancreatic (PANC-1) and breast (MDA-MB 231) cancer cell lines: a comparative study. International Journal of Nanomedicine, 573-585.
Burow, M., Wittstock, U., & Gershenzon, J. (2008). Sulfur-containing secondary metabolites and their role in plant defense. Sulfur metabolism in phototrophic organisms, 201-222.
Chatterjee, T., & Das, S. M. (2017). Antimicrobial efficacy of some medicinal plant extract against Streptococcus mutans causing dental caries. J Med Plants, 5, 315-7.
Dar, P., Faisal, M., Dar, A., & Waqas, U. (2018). Journey describing biological activities and chemical constituents in the leaves, stem bark and seed of Putranjiva roxburghii. Current Traditional Medicine, 4(4), 263-278. doi: 10.5772/intechopen.78226
Gupta, M. (2016). A review of pharmacological properties, pharmacognosy and therapeutic actions of Putranjiva roxburghii Wall. (Putranjiva). Int J Herb Med, 4(6), 104-108.
Haldar, K. M., Haldar, B., & Chandra, G. (2013). Fabrication, characterization and mosquito larvicidal bioassay of silver nanoparticles synthesized from aqueous fruit extract of Putranjiva, Drypetes roxburghii (Wall.). Parasitology Research, 112, 1451-1459.
Hasan, M. M., Tasmin, M. S., Reza, M. A., & Haque, A. (2019). Evaluation of antioxidant and antibacterial activity of Putranjiva roxburghii Wall. fruit peel. Int. J. Biosci, 15, 396-402.
Italiya, J. M., Patel, M. R., Golaviya, A. V., Patel, S. S., Thakkar, B. K., Jakhesara, S. J., ... & Koringa, P. G. (2023). RNA-sequencing attest increased sperm motility in bovine spermatozoa treated with ethanolic extract of Putranjiva roxburghii. 3 Biotech, 13(1), 33.
Kar, B., Verma, P., Patel, G. K., & Sharma, A. K. (2017). Molecular cloning, characterization and in silico analysis of a thermostable β-glucosidase enzyme from Putranjiva roxburghii with a significant activity for cellobiose. Phytochemistry, 140, 151-165.
Keshav, P., Goyal, D. K., & Kaur, S. (2021). GC–MS screening and antiparasitic action of Putranjiva roxburghii leaves against sensitive and resistant strains of Leishmania donovani. Journal of Parasitic Diseases, 45(4), 1002-1013.
Khatoon, A., Ali Khan Rao, R., & Nasar, A. (2021). Preparation and characterization of epichlorohydrin treated Putranjiva roxburghii seeds as a novel adsorbent: removal of Ni (II) from the artificial and real electroplating wastewaters. Separation Science and Technology, 56(17), 2880-2894.
Kumar, N. (2020). Phytochemistry and medicinal value of Putranjiva roxburghii Wall. Advances in pharmaceutical biotechnology: Recent progress and future applications, 133-144.
Mane, N. B., Shaikh, N. A., & Ingawale, S. V. (2021). Preliminary phytochemical screening of some compounds from leaf and stem of Putranjiva roxburghii Wall. Journal of Pharmacognosy and Phytochemistry, 10(1), 444-447.
Mangalaselvan, S. (2019). Evaluation of Antihyperlipidemic Activity of Leaves of Putranjiva roxburghii Used Against Triton Induced Hyperlipidaemic Rats (Doctoral dissertation, RVS College of Pharmaceutical Sciences, Coimbatore).
Mendoza, N., & Silva, E. M. E. (2018). Introduction to Phytochemicals: Secondary Metabolites from Plants with Active Principles for Pharmacological Importance. Phytochemicals - Source of Antioxidants and Role in Disease Prevention.
Mishra, S., Kumar, S., Darokar, M. P., & Shanker, K. (2021). Novel bioactive compound from the bark of Putranjiva roxburghii Wall. Natural Product Research, 35(10), 1738-1740.
Mishra, S., Kumar, S., Khare, S., Shukla, A., Shanker, K., Pal, A., ... & Darokar, M. P. (2023). Quebrachitol from Putranjiva roxburghii Wall. (Putranjivaceae) a potent antimalarial: pre-clinical efficacy and its interaction with PfLDH. Parasitology International, 92, 102675.
Mughal, T., & Mahboob, S. (2013). Anti-emetic activity of some members of the family, Euphorbiaceae of Lahore region. African Journal of Plant Science, 7(9), 426-431.
Murthy, K. S. R., Reddy, M. C., Kiran, A. R., & Emmanuel, S. (2013). Ethnobotany and chemistry of Drypetes roxburghii-a review. J. Trop. Med. Plants14, 109-113.
Nag, A., Bhattacharya, S., & De, K. B. (1995). New utilization of vegetable oils. Journal of the American Oil Chemists' Society, 72(12), 1591-1593.
Nawaz, R., Raja, M. U., Naz, F., Bodlah, I., & Nadir, J. (2020). Estimation efficacy of chemicals, botanicals and antagonist for the management fruit rots of grapes. J. Agric. Res, 58(2), 77-83.
Nayaka, S., Bhat, M. P., Chakraborty, B., Pallavi, S. S., Airodagi, D., Muthuraj, R., ... & Kupaneshi, C. (2020). Seed extract-mediated synthesis of silver nanoparticles from Putranjiva roxburghii Wall., phytochemical characterization, antibacterial activity and anticancer activity against MCF-7 cell line. Indian Journal of Pharmaceutical Sciences, 82(2), 260-269.
Nazli, A., Irshad Khan, M. Z., Ahmed, M., Akhtar, N., Okla, M. K., Al-Hashimi, A., ... & Haq, I. U. (2022). HPLC-DAD Based Polyphenolic Profiling and Evaluation of Pharmacological Attributes of Putranjiva roxburghii Wall. Molecules, 27(1), 68.
Panda, D. S., Padhy, S. K., Alruwaili, N. K., Gamal, M., Giri, R. K., & Patro, S. K. (2021). Phytochemical analysis and investigation of Antimicrobial and Antioxidant potential of the Leaf Extracts of Putranjiva ruxburghi. Research Journal of Pharmacy and Technology, 14(12), 6216-6222.
Patel, G.K., Kar, B., Sharma, A.K., 2012. Characterization of a thermostable family 1 glycosyl hydrolase enzyme from Putranjiva roxburghii seeds. Appl. Biochem. Biotechnol. 166, 523e535.
Rajahamsa, A. K. L., Deepak, K. S., Rao, T. K. V. K., Kumar, A. V. R. P., Reddy, G. R. S., & Potbhare, M. S. (2013). Multi-model confirmatory evaluation of anti-inflammatory, analgesic and antioxidant activities of Putranjiva roxburghii Wall. International Journal of Biomedical and Advance Research, 4(12), 921-932.
Reanmongkol, W., Noppapan, T., & Subhadhirasakul, S. (2009). Antinociceptive, antipyretic, and anti-inflammatory activities of Putranjiva roxburghii Wall. leaf extract in experimental animals. Journal of natural medicines, 63, 290-296.
Sahoo, A., Kumar, S., & Mohanty, K. (2020). A comprehensive characterization of non-edible lignocellulosic biomass to elucidate their biofuel production potential. Biomass Conversion and Biorefinery, 1-17.
Sarath, P. (2019). A comparative evaluation of phytochemicals in bark, leaves and seeds of Putranjiva roxburghii Wall. (Putranjivaceae). Journal of Pharmacognosy and phytochemistry, 8(1), 1162-1166.
Sharma, P. V. (1976). Introduction to Dravyaguna (Indian Pharmacology) (No. 5). Chaukhambha Orientalia.
Shastry, C. S., Aswathanarayana, B. J., Ganesh, S., Kalluraya, B., & Maurya, D. K. (2014). Radioprotective activity of ethanolic extract of seeds of Drypetes roxburghii Wall. in Swiss albino mice exposed to electron beam radiation.
Sudharshan, S. J., Chinmaya, A., Valleesha, N. C., Kekuda, T. R., Rajeshwara, A. N., & Syed, M. (2009). Central Nervous System (CNS) depressant and analgesic activity of methanolic extract of Drypetes roxburghii wall in experimental animal model. Research Journal of Pharmacy and Technology, 2(4), 854-857.
Tiwari, R., & Rana, C. S. (2015). Plant secondary metabolites: a review. International Journal of Engineering Research and General Science, 3(5), 661-670.
Tomar, P. P. S., Chaudhary, N. S., Mishra, P., Gahloth, D., Patel, G. K., Selvakumar, P., ... & Sharma, A. K. (2014). Purification, characterisation and cloning of a 2S albumin with DNase, RNase and antifungal activities from Putranjiva roxburghii. Applied biochemistry and biotechnology, 174, 471-482.
Tripathi, N. N., & Kumar, N. (2007). Putranjiva roxburghii oil—A potential herbal preservative for peanuts during storage. Journal of Stored Products Research, 43(4), 435-442.
Varma, A., Jain, S. K., & Alok, S. (2011). Hypoglycaemic activity of Putranjiva roxburghii wall. In alloxan induced diabetic rats. International Journal of Pharmaceutical Sciences and Research, 2(1), 160.
Verma, P., Varshney, R., Yadav, S. P. S., Kar, B., Roy, P., & Sharma, A. K. (2022). SAXS Analysis and Characterization of Anticancer Activity of PNP-UDP Family Protein from Putranjiva roxburghii. The Protein Journal, 41(3), 381-393.
Wansi, J. D., Wandji, J., Sewald, N., Nahar, L., Martin, C., & Sarker, S. D. (2016). Phytochemistry and pharmacology of the genus Drypetes: A review. Journal of ethnopharmacology, 190, 328-353.