A STUDY OF MMP7 EXPRESSION IN TRIPLE NEGATIVE BREAST CANCER PATIENTS
Keywords:MMP7, Triple negative breast cancer, Immunohistochemistry
MMP7 has a part in preventing apoptosis and promoting angiogenesis. According to both in vivo and in vitro evidence, MMP7 is mostly seen during tumour invasion and metastasis. Controlling MMP7 expression may be a method for treating this cancer because its overexpression encourages the occurrence, progression, and invasiveness of breast cancer. The aim is to study the expression of MMP7 in triple negative breast cancer patients. Formalin fixed paraffin embedded breast tumor tissues from 50 triple negative breast cancer patients were collected for this study. immunohistochemistry method was used to study MMP7 expression and correlated with clinical and pathological parameters as well as disease status. MMP7 positivity was observed in 48% triple negative breast cancer patients. No significant correlation of MMP7 expression with age, menopausal status, tumour size, histopathology, stage and lymph node status were observed. A significant higher incidence of MMP7 expression was noted in patients with high grade tumor (63%) as compared to patients with low grade tumor (00%). Further, a significant higher incidence of MMP7 was observed in patients with high BR score (65%) as compared to the patients with low BR score (00%). Also, a significant higher incidence was observed in patients with relapse (63%) than patients in remission (35%). A significant higher incidence of MMP7 expression was observed with respect to disease free survival in univariate survival analysis. In multivariate survival analysis, for disease free survival MMP7 entered at step 1 and lymph node status and MMP7 entered at step 2. The findings imply that MMP7 is important for tumour invasion and metastasis, and that elevated MMP7 expression is associated with tumour development and recurrence.
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